The formation of novel chiral bidentate phosphoroamides structures able to promote Lewis base-catalyzed Lewis acid-mediated reactions was investigated.Two different classes of phosphoroamides were synthetized: the first class presents a phthalic acid/primary diamine moiety, designed with the aim to perform a self-assembly recognition process throug
Background: Reoperation for failed hypospadias has been considered to be seriously problematic.The dense fibrotic tissue causes difficulties in wound healing and increases the rate of complications.The tubularised incised-plate urethroplasty (TIPU) method has become a preferred method for all varieties of hypospadias in the past decade.However, fis
IntroductionFentanyl and fentanyl analogs (F/FA) have become increasingly common adulterants in copyright prescription pills and illicit street drug mixtures due to their ease of synthesis and exceedingly high potency.The ongoing epidemic of fatal overdoses fueled by F/FA continues to highlight the need for longer-acting therapies than naloxone (NL
A potentially powerful predictor for the course of drug (ab)use is the approach-bias, that is, the pre-reflective tendency to approach rather than avoid drug-related stimuli.Here we investigated the neural underpinnings of cannabis approach and avoidance tendencies.By elucidating the predictive power of neural approach-bias activations for future c
Abstract Loss-of-function mutations at the retinoblastoma (RB1) gene are associated with increased mortality, metastasis, and poor therapeutic outcome in several cancers, including osteosarcoma.However, the mechanism(s) through which RB1 loss worsens clinical outcome remains understudied.Ubiquitin-like with PHD and Ring Finger domains 1 (UHRF1) has